CMS121 gaosi pa'u CAS Numera: 1353224-53-9 98.0% mama min. mo mea faaopoopo
Fua Fa'atatau
| Igoa o oloa | CMS121 |
| Isi igoa | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase,fa'ama'i,neuroprotective,fa'a'afia,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| CAS Nu. | 1353224-53-9 |
| fua mole | C20H19NO3 |
| mamafa mole | 321.37 |
| mama | 98.0% |
| Fa'aaliga | Pa'u samasama mama |
| Fa'atatauga | Mea'ai Fa'aopoopo Mea'ai |
Folasaga o oloa
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol o se tuufaatasiga e taua foi CMS121. O le lavelave o le fausaga o le tuufaatasiga ua ta'u mai ai e ono iai ni mea uiga ese ma ni mea e mafai ona faaaoga. Ina ia malamalama i lona taua, e fesoasoani e faʻailoa vaega faʻatino o loʻo i ai ma auʻiliʻili a latou aʻafiaga. O le i ai o le mama quinoline e taʻu mai ai e mafai e le faʻapipiʻi ona ola faʻapitoa. O molelaʻau e maua mai i le Quinoline e lauiloa mo a latou mea ola ola eseese, e aofia ai gaioiga faʻamaʻi ma anti-inflammatory. O le fa'apipi'iina o le vaega o le cyclopentyloxy e mafai ona saofagā i le solubility o le pa'u po'o le fa'aleleia atili o ana gaioioiga olaola e ala i a'afiaga. I suʻesuʻega i luga o sela HT22, CMS-121 ua faʻaalia ai aʻafiaga taua o le neuroprotective, puipuia lelei nei sela mai le ischemia ma le faʻaleagaina o le oxidative. E le gata i lea, o le CMS-121 o loʻo i ai ni mea taua e teteʻe ai i le faʻamaʻi, e faʻaalia ai lona gafatia e faʻafetaui tali faʻafefe. I le faia o lea mea, o le CMS-121 e mafai ona faʻaitiitia ai le mumū i totonu o aʻu ma totoga eseese. CMS-121 o loʻo i ai le malosi faʻafomaʻi gaioiga e avea o se faʻalavelave ole acetyl-CoA carboxylase 1 (ACC1). O lona a'afiaga malosi i le ACC1 ua avea ai ma fa'aputuga fa'amoemoe.
Fa'aaliga
(1) Faʻamama maualuga: CMS-121 e mafai ona maua ni oloa mama maualuga e ala i le faʻamamaina o gaosiga. O le mama maualuga o lona uiga e sili atu le bioavailability ma faʻaitiitia ai faʻalavelave leaga.
(2) Saogalemu: Saogalemu maualuga, nai mea leaga.
(3) Faʻamautu: CMS-121 o loʻo i ai le mautu lelei ma e mafai ona faʻamautu lana gaioiga ma le aʻafiaga i lalo o siosiomaga eseese ma tulaga teuina.
Talosaga
CMS-121 o se quinolone e maua mai ma olly active acetyl-CoA carboxylase 1 (ACC1) inhibitor faʻatasi ai ma mea faʻapitoa faʻafomaʻi. O suʻesuʻega lautele na faʻatautaia e suʻesuʻe ai le aoga o le CMS-121 i vaega eseese, e aofia ai le neuroprotection, anti-inflammatory effects, antioxidant activity, ma lona aʻafiaga i luga o faʻailoga e fesoʻotaʻi ma le soifua maloloina.
