5-amino-1-methylquinolinium iodide CAS Numera:42464-96-0 98.0% mama min. | fa'aopoopo mea e gaosi ai mea'ai
Fua Fa'atatau
| Igoa o oloa | 5-amino-1-methylquinolinium iodide |
| Isi igoa | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-umiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS Nu. | 42464-96-0 |
| fua mole | C10H11IN2 |
| mamafa mole | 286.11 |
| mama | 98% |
| Fa'aaliga | Enaena enaena enaena mumu mumu |
| afifiina | 1kg / taga, 25kg / paelo |
| Fa'aaogāga | Mea'ai Fa'aopoopo Mea'ai |
Folasaga o oloa
O le NNMTi o se enzyme e sili atu ona faʻaalia i le taimi o le matua o le maso o le skeletal ma e fesoʻotaʻi ma le toe faʻaleleia o le ala NAD + faʻaleagaina, faʻaleagaina le sirtuin1 gaioiga, ma le faʻateleina o le musele o le tino. NNMTi faʻalauiloaina le eseesega o le myoblast in vitro ma faʻaleleia le fusi ma le toe faʻafouina o sela o maso i isumu matutua. O le NNMTi o se faʻalavelave malosi foi o le nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), faʻapipiʻi faʻapipiʻi i toega nofoaga o loʻo fusifusia ai substrate NNMT. NNMTi faʻalauiloaina le eseesega o le myoblast in vitro ma faʻaleleia le fusi ma le toe faʻafouina o sela o maso i isumu matutua. Faatasi ai ma i latou, o le cytosolic enzyme nicotinamide N-methyltransferase (NNMT) ua maua fou e faʻatonutonu ai le maualuga o nicotinamide precursors e manaʻomia mo le NAD + biosynthesis, ma o lea e iai sona sao taua i le faʻatonutonuina o le NAD + salvage ala ma le metabolism cellular.
Fa'aaliga
(1) Faʻamama maualuga: NNMTi e mafai ona maua ni oloa mama maualuga e ala i le faʻamamaina o gaioiga gaosiga. O le mama maualuga o lona uiga e sili atu le bioavailability.
(2) Faʻatatau: NNMTi faʻapitoa faʻatatau i le NNMT enzyme ma e mafai ona faʻamalosia lelei lana gaioiga, ma faʻapea ona aʻafia ai le ala gasegase o le nicotinamide.
(3) Faʻamautu: NNMTi o loʻo i ai le mautu lelei ma e mafai ona faʻatumauina lana gaioiga ma le aʻafiaga i lalo o siosiomaga eseese ma tulaga teuina.
(4) Atinaʻe faʻamoemoega: Ona o uiga eseese o le NNMT, o lona atinaʻe ua maua le faʻalauteleina o le gauai ma le lautele o suʻesuʻega ma faʻamoemoega talosaga.
Talosaga
NNMTi o le nicotinamide N-methyltransferase (NNMT) inhibitor e faʻamalosia ai le eseesega o le myoblast. NNMTi e mafai foi ona faʻaaogaina e fai ma faʻaopoopoga e fesoasoani e faʻaitiitia le mamafa ma le gaʻo ma faʻaleleia le gaʻo ate.
