5-Amino-1-methylquinolinium chloride CAS No.:42464-96-0 98.0% mama maualalo | gaosi oloa fa'aopoopo
Fa'asologa o Oloa
| Igoa o le oloa | 5-Amino-1-methylquinolinium chloride（5-amino-1MQ） |
| Isi igoa | 5-amino-1MQ5-Amino-1-mq chloride 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Numera CAS. | 42464-96-0 |
| Fa'asologa molekiula | C₁₀H₁₁ClN₂ |
| Mamafa molekiula | 194.6 |
| Mama | 98% |
| Foliga vaaia | Enaena i le enaena mumu |
| afifiina | 1kg/taga, 25kg/paelo |
| Talosaga | Meafaitino Mata mo le Fa'aopoopoga o Mea'ai |
Fa'atomuaga o le oloa
O le 5-Amino-1-methylquinolinium chloride o se enzyme e tele naua lona fa'aalia i le taimi o le matua o maso o le skeletal ma e feso'ota'i ma le toe fa'aleleia o le fa'aleagaina o le auala NAD+, le fa'aletonu o le gaioiga o le sirtuin1, ma le fa'ateleina o le matua o sela o maso. O le 5-Amino-1-methylquinolinium chloride e fa'alauiloa ai le eseesega o myoblast i totonu o le vitro ma fa'aleleia atili ai le tu'ufa'atasia ma le toe fa'afouina o sela o maso i isumu ua matutua. O le 5-Amino-1-methylquinolinium chloride o se mea malosi fo'i e taofia ai le nicotinamide N-methyltransferase (NNMT), e fusifusia fa'apitoa i toega o nofoaga e fusifusia ai le substrate NNMT. O le 5-Amino-1-methylquinolinium chloride e fa'alauiloa ai le eseesega o myoblast i totonu o le vitro ma fa'aleleia atili ai le tu'ufa'atasia ma le toe fa'afouina o sela o maso i isumu ua matutua. O se tasi o ia mea, o le cytosolic enzyme nicotinamide N-methyltransferase (NNMT) ua fa'ato'ā maua e fa'atonutonu ai le maualuga o nicotinamide precursors e mana'omia mo le NAD+ biosynthesis, ma o lea e iai sona sao taua i le fa'atonutonuina o le auala salvage NAD+ ma le metabolism o sela.
E galue le 5-Amino-1-Methylquinolinium Chloride i totonu o lau microbiome e faʻaitiitia ai le gaʻo (asu) ma fesoasoani ia te oe e faʻaitiitia ai lou mamafa. A faʻaputuina ni sela gaʻo faʻaopoopo, e soʻona gaosia e lou tino se enzyme e taʻua o le NNMT (nicotinamide N-methyltransferase). O le tele o le NNMT, o le tele foʻi lea o le faʻateleina o le mumū ma teuina ai gaʻo e lou tino. E taofia e le 5-Amino-1-Methylquinolinium Chloride le NNMT, ma mafai ai e lou tino ona faʻaitiitia le mamafa tele.
Vaega
(1) Mama maualuga: E mafai e le 5-Amino-1-methylquinolinium chloride ona maua ni oloa mama maualuga e ala i ni faiga gaosiga ua faaleleia. O le mama maualuga o lona uiga o le sili atu ona lelei le bioavailability.
(2) Fa'atatauga: O le 5-Amino-1-methylquinolinium chloride e fa'atatau tonu lava i le enzyme NNMT ma e mafai ona taofia lelei lana gaioiga, ma a'afia ai le auala o le metabolism o le nicotinamide.
(3) Mausali: O le 5-Amino-1-methylquinolinium chloride e mausalī lelei ma e mafai ona faatumauina lona gaioiga ma lona aafiaga i lalo o siosiomaga eseese ma tulaga o le teuina.
(4) Fa'amoemoega o le atina'eina: Ona o uiga eseese o le 5-Amino-1-methylquinolinium chloride, ua maua ai e le to'atele le gauai i lona atina'eina ma ua i ai su'esu'ega lautele ma fa'amoemoega mo le fa'aaogaina.
Talosaga
O le 5-Amino-1-methylquinolinium chloride o se nicotinamide N-methyltransferase (NNMT) inhibitor e fa'aleleia ai le myoblast differentiation. E mafai fo'i ona fa'aaoga le 5-Amino-1-methylquinolinium chloride o se fa'aopoopoga e fesoasoani e fa'aitiitia ai le mamafa ma ga'o ma fa'aleleia atili ai le ga'o o le ate.
