Oleoylethanolamide (OEA) gaosi pa'u CAS Numera: 111-58-0 98%,85% mama min. mo mea faaopoopo
Fua Fa'atatau
| Igoa o oloa | Oleoyl ethanolamide |
| Isi igoa | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| CAS Nu. | 111-58-0 |
| fua mole | C20H39NO2 |
| mamafa mole | 325.53 |
| mama | 98.0% ，85.0% |
| Fa'aaliga | Pa'u tioata pa'epa'e lelei |
| afifiina | 1kg/pe, 25kg/tapa |
| Fa'atatauga | Fa'amama tiga, fa'ama'i |
Folasaga o oloa
Oleoylethanolamide ose lua amide faʻapipiʻi e aofia ai le lipophilic oleic acid ma le hydrophilic ethanolamine. Oleoylethanolamide ose mole mole lipid e masani ona tupu i isi meaola ma laau toto. O lo'o i ai lautele i aano o manu ma la'au e pei o le koko pauta, soya, ma nati, ae o lona mea e matua maualalo lava. Na'o le taimi lava e suia ai le siosiomaga i fafo pe fa'aosofia mea'ai, o auga o le tino ona faatoa maua ai lea o le tele o lenei mea.
I le vevela o le potu, Oleoylethanolamide o se paʻepaʻe paʻepaʻe ma se mea faʻafefe e tusa ma le 50°C. E faigofie ona solu i solvents ava malosi e pei o le methanol ma ethanol, sili atu ona soluble i solvents non-polar pei ole n-hexane ma eter, ma le mafai ona solu i le vai. OEA o se mole mole amphiphilic e masani ona faʻaaogaina e avea o se faʻamaʻi ma faʻamama i totonu o pisinisi kemisi. Ae ui i lea, o nisi suʻesuʻega na maua ai o le OEA e mafai ona avea o se lipid signaling mole i totonu o le gut-brain axis ma faʻaalia se faasologa o gaioiga faʻaola i totonu o le tino, e aofia ai: pulea le manaʻo, faʻaleleia le metabolism lipid, faʻaleleia le mafaufau ma le mafaufau ma isi galuega. Faatasi ai ma i latou, o galuega a Oleoylethanolamide o le puleaina o le manaʻo ma le faʻaleleia o le lipid metabolism ua sili ona gauai.
Oleoylethanolamide e mafai ona faʻatonutonuina meaʻai ma le malosi homeostasis e ala i le faʻagaoioia o le peroxisome proliferator-activated receptor-α. E le gata i lea, ole Oleoylethanolamide o loʻo faʻaalia isi gaioiga e fesoʻotaʻi ma le soifua maloloina, e aofia ai le faʻaogaina o gaioiga liliu i le lysosomal-to-nuclear signaling pathway e fesoʻotaʻi ma tulafono faatonutonu umi ma le puipuia o neura e pulea ai amioga faʻavaivai. O suʻesuʻega foʻi e faʻaalia ai ole Oleoylethanolamide e ono iai ni aʻafiaga o le neuroprotective. I faʻataʻitaʻiga manu, ua maua e faʻaitiitia ai le faʻaleagaina mai le taʻavale ma le manua o le faiʻai. O le faʻatonuga o le Oleoylethanolamide e mafua ona o lona fusifusia i le PPARα, lea e faʻaititia ma le retinoid X receptor (RXR) ma faʻagaoioia e avea o se faʻamatalaga malosi e aʻafia i le tuʻufaʻatasiga o le homeostasis, lipid metabolism, autophagy, ma le mumū. pito i lalo.
Fa'aaliga
(1) maualuga mama: OEA e mafai ona maua oloa maualuga-mama e ala i le faamamaina o faiga gaosiga. O le mama maualuga o lona uiga e sili atu le bioavailability ma faʻaitiitia ai faʻalavelave leaga.
(2) Saogalemu: OEA ua faʻamaonia e saogalemu mo le tino o le tagata.
(3) Fa'amautu: OEA e lelei le mautu ma e mafai ona fa'atumauina lona gaioiga ma le a'afiaga i lalo o si'osi'omaga eseese ma tulaga e teu ai.
(4) Faʻafaigofie ona faʻafefe: OEA e mafai ona vave faʻafefe e le tino o le tagata ma tufatufa atu i aano ma totoga eseese.
Talosaga
Oleoylethanolamide ose lipid ethanolamide fa'anatura fa'aaogaina e fai ma fuafuaga o mea'ai ma le fa'atonutonuina o le mamafa o le tino i ituaiga eseese o vetebrate. O se metabolite ole oleic acid e fausia ile tootoo laiti ole tagata. Oleylethanolamide (OEA) o se mole e faʻatonutonuina le lipid metabolism ma le malosi homeostasis. E pipii i le PPAR Alpha receptors ma fesoasoani e pulea mea e fa: fia'ai, ga'o o le tino, cholesterol ma le mamafa. O le PPAR Alpha o loʻo faʻatusalia ai le alpha, ma o le bioactive lipid amide oleoylethanolamide (OEA) o loʻo i ai le tele o mea faʻapitoa ile homeostatic, e aofia ai le anti-inflammatory activity, immune response modulation, ma antioxidant effects.
